#5-83E. Navigating Steroid Tapering: Joint Guidelines on Glucocorticoid-Induced Adrenal Insufficiency (JCEM, 2024)

How can clinicians safely manage and discontinue long-term glucocorticoid therapy while mitigating the risk of secondary adrenal insufficiency? This joint guideline from the European Society of Endocrinology and the Endocrine Society offers structured recommendations, emphasizing pragmatic tapering strategies and the utility of morning serum cortisol cut-offs over routine dynamic testing. However, clinicians should note that many recommendations are based on low-quality evidence and expert consensus due to a paucity of rigorous randomized controlled trials. Ultimately, these guidelines equip practitioners with a standardized framework to prevent adrenal crises and safely guide steroid withdrawal in routine care.

Citation: Beuschlein F, Else T, Banos I, et al. European Society of Endocrinology and Endocrine Society Joint Clinical Guideline: Diagnosis and Therapy of Glucocorticoid-induced Adrenal Insufficiency. The Journal of Clinical Endocrinology & Metabolism. 2024. DOI: 10.1210/clinem/dgae250

URL: https://doi.org/10.1210/clinem/dgae250

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