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#5-76E. Navigating Pulmonary Nodules: Risk Stratification and Biopsy Choices (NEJM, 2026)
2026年9月25日 12:00·5分46秒
How can clinicians effectively distinguish malignant pulmonary nodules from benign lesions while avoiding unnecessary invasive procedures? This review highlights that subsolid nodules require prolonged surveillance of at least four years due to their indolent growth, whereas navigational bronchoscopy offers comparable diagnostic accuracy to needle biopsy with significantly lower complication rates. However, prospective trials reveal variable diagnostic yields for advanced guided techniques, highlighting the challenge of avoiding over-testing in benign disease. Ultimately, integrating risk-prediction models empowers physicians to personalize management, balancing prompt oncologic intervention against noninvasive surveillance.
Citation: Matthew E.J. Callister, Gerard A. Silvestri. Pulmonary Nodules. New England Journal of Medicine. 2026. DOI: 10.1056/NEJMcp2515063
URL: https://doi.org/10.1056/NEJMcp2515063
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