#5-86E. Decoding the Skin–Joint Axis: How Psoriatic Plaques Seed Synovial Inflammation (Nat Rev Rheumatol, 2026)

How do skin lesions in psoriasis transition into destructive musculoskeletal inflammation in psoriatic arthritis? Emerging single-cell RNA sequencing and lineage-tracing evidence directly demonstrates that skin-derived T-cell clones and myeloid precursors migrate to the synovium, though progression depends on joint stromal permissiveness—a model still primarily anchored in small clinical cohorts and preclinical models needing longitudinal validation. Understanding this functional skin–joint continuum equips clinicians to identify high-risk patients early and leverage multi-compartment biomarkers for timely, proactive disease interception in daily practice.

Citation: Raimondo MG, Gandolfo S, Gensler LS, Thomas R, Schett G, Ramming A, Ciccia F. From psoriatic plaque to synovium: decoding the skin–joint axis in psoriatic arthritis. Nature Reviews Rheumatology. 2026.DOI: 10.1038/s41584-026-01412-3

URL: https://doi.org/10.1038/s41584-026-01412-3

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