#5-99E. Streamlining Delabeling: Comparative Effectiveness of Same-Day Multi-Antibiotic Evaluation (JACI Pract, 2026)

How can clinicians efficiently manage patients burdened with multiple low-risk antibiotic allergy labels without causing delays and care fragmentation? This 10-year comparative effectiveness study demonstrates that a single-visit, consolidated evaluation strategy (MAAES) dramatically improves delabeling success to 97.4% compared to 79.6% with traditional multi-visit pathways, while reducing loss to follow-up and adverse events; however, its retrospective single-center design introduces potential selection bias. For practicing physicians, adopting a same-day multidrug evaluation protocol offers a safe, practical framework to restore first-line antibiotic access and optimize antimicrobial stewardship in outpatient settings.

Citation: Ratchataswan T, Lee R, Asiaee A, Krantz MS, Koo G, Stone CA Jr, Phillips EJ. Multiple Antibiotic Allergy Evaluation Strategy (MAAES): A Comparative Effectiveness Study. J Allergy Clin Immunol Pract. 2026.

URL: https://doi.org/10.1016/j.jaip.2026.07.005

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