#5-82E. Maternal Dietary Allergen Intake and Infant Allergy Prevention: Findings from the PrEggNut Trial (NEJM, 2026)

Can high maternal intake of eggs and peanuts during pregnancy and lactation prevent IgE-mediated food allergies in high-risk infants? In the randomized PrEggNut trial involving over 2,000 mother-infant pairs, high maternal consumption of eggs and peanuts from early gestation through four months of lactation failed to significantly reduce infant egg or peanut allergy at one year compared to standard intake (7.8% vs. 8.4%), though lower-than-anticipated overall allergy prevalence may have reduced statistical power. Consequently, clinicians should emphasize direct infant allergen introduction around six months of age rather than advising excessive maternal dietary loading.

Citation: Debra J. Palmer, Dianne E. Campbell, Ralph Nanan, et al. Trial of a Maternal Diet Rich in Eggs and Peanuts to Reduce Infant Allergy. The New England Journal of Medicine. 2026. DOI: 10.1056/NEJMoa2605659

URL: https://doi.org/10.1056/NEJMoa2605659

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