#5-78E. Unraveling Placental Pathology: Non-Thrombotic Immune Mechanisms in SLE Pregnancies (Front Immunol, 2022)

Why do pregnancies complicated by systemic lupus erythematosus suffer high rates of adverse outcomes despite standard antithrombotic management? This narrative review demonstrates that placental damage is driven not only by thrombotic lesions, but significantly by non-thrombotic inflammatory pathways—such as complement hyperactivation, neutrophil extracellular traps, and dysregulated cytokine signaling—though as a narrative overview, it lacks systematic study selection and quantitative meta-analytic evidence. Recognizing these distinct immunological drivers empowers clinicians to expand beyond conventional anticoagulation, encouraging personalized risk stratification and targeted anti-inflammatory strategies to safeguard high-risk maternal and fetal lives.

Citation: Castellanos Gutierrez AS, Figueras F, Morales-Prieto DM, Schleußner E, Espinosa G, Baños N. Placental damage in pregnancies with systemic lupus erythematosus: A narrative review. Frontiers in Immunology. 2022. DOI: 10.3389/fimmu.2022.941586

URL: https://doi.org/10.3389/fimmu.2022.941586

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