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#6-09E. From Speculation to Science: How Tonegawa’s Discovery of Gene Rearrangement Reshaped Immunology (Nat Immunol, 2026)
2026年10月28日 13:00·5分28秒
How does the human immune system generate vast antibody diversity without possessing an infinite genome? In this retrospective obituary, Mark M. Davis highlights Susumu Tonegawa’s revolutionary discovery of genomic rearrangement in immunoglobulin genes, which replaced speculative theories with concrete molecular evidence. Although this narrative reflection lacks new empirical clinical trial data, it underscores the profound paradigm shift toward data-driven immunology. For practicing physicians, appreciating this molecular foundation reinforces the critical importance of grounding clinical reasoning and immunological diagnoses in rigorous genomic mechanisms rather than unverified hypotheses.
Citation: Mark M. Davis. Susumu Tonegawa (1939–2026). Nature Immunology. 2026. DOI: 10.1038/s41590-026-02660-x
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