#1-100E. The Intersection of Vasculitis and Hematologic Malignancy: A Collaborative Approach (A&R, 2025)

When should we suspect an underlying hematologic malignancy in a patient presenting with systemic vasculitis? This expert perspective from Arthritis & Rheumatology explores the diagnostic and therapeutic challenges of vasculitis with concomitant hematologic malignancy (VCHM), a rare but critical clinical scenario. Through a detailed case presentation and review, the authors outline a collaborative approach between rheumatology and hematology, highlighting key clinical features, imaging findings, and molecular diagnostics that can guide an accurate diagnosis. The paper's most critical takeaway is the strong recommendation to consider hematologic malignancy in the differential for any vasculitis patient, especially those with atypical findings like cytopenias or monocytosis, and to pursue early hematology consultation. However, it is important to note that this is an expert review based on clinical experience and limited retrospective data, not a high-level evidence-based guideline. For clinicians, this article underscores the necessity of interdisciplinary collaboration, offering a practical framework for managing these complex cases.

Citation: ROBINETTE, Michelle L. and Hetty E. CARRAWAY. Expert Perspective: Hematologic Malignancies and Vasculitis. Arthritis & Rheumatology. 2025, vol. 77, no. 10, pp. 1305–1316. DOI: 10.1002/art.431951.

Disclaimer: This audio summary is based on personal interpretation and does not guarantee the exact content of the original paper. Please refer to the original article for details.