#5-72E. Unmasking RS3PE: Clinical Associations, Paraneoplastic Risks, and Management (J Investig Med, 2020)

How can clinicians quickly distinguish benign distal extremity swelling from a sinister underlying disease in elderly patients? This comprehensive review highlights that remitting seronegative symmetrical synovitis with pitting edema (RS3PE) serves as a distinct inflammatory syndrome often triggered by malignancies or drug therapies like immune checkpoint inhibitors. While the synthesis is inherently limited by reliance on small case reports subject to publication bias, markedly elevated serum MMP-3 levels or steroid refractoriness should prompt an urgent search for hidden cancer. Recognizing RS3PE enables timely low-dose corticosteroid treatment and critical malignancy screening in routine clinical practice.

Citation: Lakhmalla M, Dahiya DS, Kichloo A, Fatima T, Edigin E, Wani F. Remitting seronegative symmetrical synovitis with pitting edema: a review. Journal of Investigative Medicine. 2020. DOI: 10.1136/jim-2020-001613

URL: https://doi.org/10.1136/jim-2020-001613

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