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#6-25E. Beyond Traditional Criteria: Antiphospholipid Antibodies and Cardiovascular Thrombosis Risk (Nat Rev Cardiol, 2026)
2026年11月13日 12:00·6分33秒
Are we underestimating cardiovascular thrombotic risk in patients with antiphospholipid antibodies who fall outside traditional criteria for antiphospholipid syndrome? This comprehensive review demonstrates that antiphospholipid antibody seropositivity significantly increases arterial and venous thrombotic risk across broader populations, while noting that direct oral anticoagulants are less effective than vitamin K antagonists in established cases. Crucially, clinicians must consider that widespread assay variability and unconfirmed antibody persistence in many studies risk outcome misclassification. Ultimately, recognizing this broader seropositive spectrum enables physicians to refine risk stratification and make better-informed antithrombotic treatment decisions in unexplained vascular events.
Citation: Rashedi S, Leyva H, Siddiqui SA, et al. Antiphospholipid antibodies and cardiovascular thrombosis. Nature Reviews Cardiology. 2026. DOI: 10.1038/s41569-026-01269-9
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