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#5-65E. Statins in Older Adults: Heart Protection without Independence? (N Engl J Med, 2026)
2026年9月14日 12:00·6分8秒
Should we routinely initiate statins for primary prevention in older adults to extend their independent life? The landmark STAREE trial revealed that while daily atorvastatin significantly reduced major cardiovascular events in patients aged 70 or older, it failed to prolong disability-free survival. However, clinicians should note that the trial predominantly enrolled healthy, White, English-speaking participants, which may limit generalizability to frailer or more diverse patient cohorts. These findings suggest that prescribing statins in later life requires a nuanced, patient-centered discussion that weighs cardiac benefits against overall quality of life and functional independence.
Citation: Zoungas S, et al. Atorvastatin, Cardiovascular Events, and Disability-free Survival in Older Adults. The New England Journal of Medicine. 2026. DOI: 10.1056/NEJMoa2607314
URL: https://doi.org/10.1056/NEJMoa2607314
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