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#5-73E. Navigating Modern Treatment Decisions in Multiple Myeloma: From Quadruplets to T-Cell Redirection (NEJM, 2026)
2026年9月22日 12:00·4分45秒
How can clinicians navigate the increasingly complex therapeutic landscape of multiple myeloma as survival extends toward potential functional cures? This review establishes an individualized framework integrating 2025 IMS-IMWG genomic risk stratification, functional fitness, and measurable residual disease to guide quadruplet inductions and early T-cell redirecting therapies. While many risk-adapted strategies reflect expert consensus and evolving clinical trial data rather than long-term randomized proof, this guide provides a practical roadmap for sequencing CAR T-cell therapies and bispecific antibodies to optimize patient outcomes.
Citation: Tarek H. Mouhieddine, Kenneth C. Anderson. Treatment Decisions in Multiple Myeloma. New England Journal of Medicine. 2026. DOI: 10.1056/NEJMra2605253
URL: https://doi.org/10.1056/NEJMra2605253
Disclaimer: This audio summary is based on personal interpretation and does not guarantee the exact content of the original paper. Please refer to the original article for details.
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