#5-55E. Navigating the Uncharted: International Consensus on Rare SLE Manifestations (Lancet Rheumatol, 2026)

How should you manage life-threatening, rare manifestations of systemic lupus erythematosus when clinical trials are virtually non-existent? This newly released consensus paper addresses this gap by defining severity-graded therapeutic algorithms for twenty-two rare manifestations, such as diffuse alveolar hemorrhage. However, clinicians must critically note that these recommendations are based on expert consensus rather than high-level trial evidence. Ultimately, this framework serves as an invaluable clinical compass, empowering clinicians to make standardized, rapid decisions for rare, high-risk lupus manifestations in daily practice.

Citation: Arnaud, Laurent, et al. ERN ReCONNET–SLICC–SLEuro consensus on the therapeutic management of rare systemic lupus erythematosus manifestations (part 2). Lancet Rheumatol. 2026. DOI: 10.1016/S2665-9913(26)00141-4

URL: https://doi.org/10.1016/S2665-9913(26)00141-4

Disclaimer: This audio summary is based on personal interpretation and does not guarantee the exact content of the original paper. Please refer to the original article for details.