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#6-13E. Trained Immunity in Chronic Joint Inflammation: A New Paradigm for Rheumatic Diseases (Nat Rev Rheumatol, 2026)
2026年11月1日 13:00·6分12秒
How do inflammatory joint diseases remain self-sustaining even when primary triggers wane? This review highlights maladaptive trained immunity—metabolic and epigenetic reprogramming of myeloid progenitors and joint-resident cells—as a core driver perpetuating chronic and relapsing inflammation in arthritis, although direct experimental evidence in osteoarthritis and calcium pyrophosphate deposition disease remains limited. Recognizing this innate immune memory shifts clinical focus toward early local intervention and metabolic-epigenetic therapies, offering a novel strategy to break persistent inflammatory cycles and reduce systemic cardiovascular risks in patients with chronic joint disease.
Citation: Kischkel B, Nasi S, Leroy C, Joosten LAB, Ea HK. Trained immunity in chronic, relapsing and low-grade joint inflammation. Nature Reviews Rheumatology. 2026.
DOI: 10.1038/s41584-026-01439-6
Disclaimer: This audio summary is based on personal interpretation and does not guarantee the exact content of the original paper. Please refer to the original article for details.
